I don't know where to post this? I found a bug but also found a work-around.
Last night I unplugged my headphones from my PC, I had been using the 'narrator' play by play (windows warned me my audio was removed) and when I returned to play again and launched the game I received a run-time 2.##### error and the game crashed. I repeated this three times and then I set out to figure out why. I turned off all sound in the settings and the game launched. I later plugged my headphones back in and turned sound on and all worked.